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Viscus© flywheel cycle ergometer. Used to study active-assisted recovery following total knee arthroplasty

Simon J. Lees, Ph.D.

In the Skeletal Muscle Cell Biology Lab, we study several areas in biomedical research.  We have a fully translational program with projects spanning cell-based research, pre-clinical animal models, and clinical/rehabilitation programs. These include:

  • Studying the age-related loss of skeletal muscle mass, known as sarcopenia, and a diminished capacity for skeletal muscle regeneration. 

  • Investigating the influence of low-dose radiation on cell function.

  • Determining the effects of in utero stress on metabolism.

  • Examining mechanisms leading to improved glucose uptake and insulin sensitivity in peripheral tissues.

  • Investigating brown adipose tissue metabolism using micro positron emission tomography (microPET).

  • Leading multidisciplinary teams involving physicians, physiotherapists, occupational therapists, nurses, dietitians, and research assistants in the community, hospitals, and rehabilitation centres.  These purpose of these projects is to establish evidence-based changes to standard of care. These include:

    • Enhanced recovery programs following total joint arthroplasty​

    • Establishing new prehabilitation treatment protocols prior to total joint arthroplasty

    • Establishing activity recovery programs to treat post-concussive syndrome

  • Exploring novel combination cancer therapies using microPET.

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